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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as focusing on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographical regions. This type of heterogeneity is necessary for practical trials to be valid and also helps to reduce bias in the results. However, too much heterogeneity can lead to problems with the design of the trial.

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Mobile compatibility

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Legality

Pragmatic Play has gained a reputation for offering top-notch games and an exceptional user experience. Its software is designed to work with mobile devices and is compatible with multiple languages. Despite its relatively young age it has established itself as a leading casino gaming platform. The most recent releases include Wolves which is a five-reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically requested by practitioners and policymakers in order to guide their decisions. They can be used to determine the causality of an intervention and its results. However, they should not be used to substitute for explanatory studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove a physiological or clinical hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the features of a pragmatic study which includes recruitment, design and delivery of the intervention, as well as monitoring.

The number of pragmatic trials is growing. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of studies were conducted in primary care settings.